Testicular Germ Cell Tumors Acquire Cisplatin Resistance by Rebalancing the Usage of DNA Repair Pathways

Testicular Germ Cell Tumors Acquire Cisplatin Resistance by Rebalancing the Usage of DNA Repair Pathways

Despite germ cell tumors (GCTs) responding to cisplatin-based chemotherapy at a high rate, a subset of patients does not respond to treatment and have significantly worse prognosis. The biological mechanisms underlying the resistance remain unknown. In this study, by using two TGCT cell lines that h...

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Bibliographic Details
Main Authors: Cinzia Caggiano, Francesca Cavallo, Teresa Giannattasio, Gioia Cappelletti, Pellegrino Rossi, Paola Grimaldi, Darren R. Feldman, Maria Jasin, Marco Barchi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
TGCT
53BP1
DNA-PKcs
cisplatin resistance
HR
NHEJ
Online Access:https://www.mdpi.com/2072-6694/13/4/787

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