Interventional effect of tiotropium bromide combined with aminophylline on pulmonary function and inflammatory factors of patients with chronic obstructive pulmonary disease

• Main Authors: Shui Gao, Si-Yu Chen
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-08-01
• Series: Journal of Hainan Medical University
• Subjects: Tiotropium bromide; Aminophylline; COPD; Pulmonary function; Inflammatory factors
• Online Access: http://www.hnykdxxb.com/PDF/201615/9.pdf

Objective: To observe the interventional effect of tiotropium bromide combined with aminophylline on pulmonary function and inflammatory factors of patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 170 cases of patients with COPD in our hospital from January 2013 to December 2015 were selected and randomly divided into the Group A (observation group, n=85) and Group B (control group, n=85). The Group B was treated with aminophylline (0.1 g/time, 2 times /d), the Group A received tiotropium bromide (18 μg/time, 1 time/d) on the basis of the Group B. The levels of interleukin-8 (IL-8), high sensitive C reactive protein (hs-CRP) and tumor necrosis factor alpha (TNF-α) were detected. The index of airway remodeling in patients with chest CT examination, pulmonary function indices were detected by chest pulmonary function instrument. Results: After treatment, the levels of inflammatory factors IL-8, hs-CRP and TNF-α, and the indices of airway remodeling WA% and T/D in two group were significantly decreased (P<0.05), while levels of inflammatory factors and index of airway remodeling in Group A were significantly lower than that of in Group B (P<0.05). The FEV1, FVC and FEV1/FVC of lung function indices were significantly improved in patients of two group (P<0.05), while the Group A was better than Group B (P<0.05). The total efficiency of Group A and Group B were 88.24% and 74.12% respectively. The Group A was significantly higher than the Group B (x2=5.543, P<0.05). Conclusions: Tiotropium bromide combined with aminophylline can significantly reduce the inflammatory factor level in patients with COPD and effectively improve the pulmonary function, with satisfactory curative effect in clinical treatment.