Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

• Main Authors: Meng Zhang, Jukka P. Matinlinna, James K.H. Tsoi, Wenlong Liu, Xu Cui, William W. Lu, Haobo Pan
• Format: Article
• Language: English
• Published: Elsevier 2020-05-01
• Series: Journal of Orthopaedic Translation
• Subjects: Allograft; Artificial material; Autograft; Biomaterial; Long-bone segmental defect reconstruction; Tissue engineering
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214031X19302098

Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.