Recent Advances of Nanocarriers for Effective Delivery of Therapeutic Peptides

• Main Authors: Mona Atabakhshi-Kashi, Marzieh Geranpayehvaghei, Yazhou Wang, Hamidreza Akhbariyoon, Mohammad Taleb, Yinlong Zhang, Khosro Khajeh, Guangjun Nie
• Format: Article
• Language: English
• Published: Andover House Inc.
• Series: Precision Nanomedicine
• Online Access: http://prnano.scholasticahq.com/article/13444-recent-advances-of-nanocarriers-for-effective-delivery-of-therapeutic-peptides.pdf

Precisely selective interactions of peptides with their unique binding partners represent an outstanding starting point for designing novel therapeutics. It is well established that peptides with a variety of critical physiological functions and specific mechanisms of action offer distinct advantages including admirable safety and higher efficiency over traditional small molecule therapeutics. Certain intrinsic weaknesses of naturally occurring peptides such as negligible plasma half-life, low bioavailability, and potential immunogenicity have limited their administration as medicines. Nanotechnology has expanded several promising strategies to address the limitations associated with therapeutic peptides. This review aims to perform a state-of-the-art summary of the strategies that are actively used to develop efficient formulations of nanosystem based peptide medicines. We first focus on the recent advances and updates on peptide-based nanomedicines. Then we indicate how nanosystems improved the functionality of therapeutic peptides and what the future opportunities and challenges of developments in the field of therapeutic peptides are. Potential noninvasive delivery platforms for peptide incorporated nanoparticles through alternative administration routes are also discussed.