Carbon fluoroxide nanoparticles as fluorescent labels and sonosensitizers for theranostic applications

• Main Authors: Alexander Kharin, Olga Syshchyk, Alain Geloen, Sergey Alekseev, Andrey Rogov, Vladimir Lysenko, Victor Timoshenko
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2015-07-01
• Series: Science and Technology of Advanced Materials
• Subjects: nanoparticles; theranostics; ultrasound; carbon; luminescence; bioimaging
• Online Access: http://dx.doi.org/10.1088/1468-6996/16/4/044601

Carbon fluoroxide (CFO) nanoparticles (NPs) produced from silicon carbide wafers are used as both fluorescent probes and sonosensitizers for theranostic application. In vitro cell tests were carried out to investigate the feasibility of ultrasound-based therapy with the use of the CFO NPs. The NPs that penetrated inside the cells were shown to provoke cell destruction after application of an ultrasound treatment. No significant toxic effect was observed when the cells were treated with NP concentrations up to 0.5 mg ml−1 without applying ultrasound treatment. The obtained results open a new way toward cancer therapy strategies.