Carbon fluoroxide nanoparticles as fluorescent labels and sonosensitizers for theranostic applications

Carbon fluoroxide nanoparticles as fluorescent labels and sonosensitizers for theranostic applications

Carbon fluoroxide (CFO) nanoparticles (NPs) produced from silicon carbide wafers are used as both fluorescent probes and sonosensitizers for theranostic application. In vitro cell tests were carried out to investigate the feasibility of ultrasound-based therapy with the use of the CFO NPs. The NPs t...

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Bibliographic Details
Main Authors: Alexander Kharin, Olga Syshchyk, Alain Geloen, Sergey Alekseev, Andrey Rogov, Vladimir Lysenko, Victor Timoshenko
Format: Article
Language:English
Published: Taylor & Francis Group 2015-07-01
Series:Science and Technology of Advanced Materials
Subjects:
nanoparticles
theranostics
ultrasound
carbon
luminescence
bioimaging
Online Access:http://dx.doi.org/10.1088/1468-6996/16/4/044601
Description
Summary:Carbon fluoroxide (CFO) nanoparticles (NPs) produced from silicon carbide wafers are used as both fluorescent probes and sonosensitizers for theranostic application. In vitro cell tests were carried out to investigate the feasibility of ultrasound-based therapy with the use of the CFO NPs. The NPs that penetrated inside the cells were shown to provoke cell destruction after application of an ultrasound treatment. No significant toxic effect was observed when the cells were treated with NP concentrations up to 0.5 mg ml−1 without applying ultrasound treatment. The obtained results open a new way toward cancer therapy strategies.
ISSN:1468-6996
1878-5514

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