Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD

Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a chronic disease that causes excessive hepatic lipid accumulation. Reducing hepatic lipid deposition is a key issue in treatment and inhibition of NAFLD evolution. Silymarin is a potent hepatoprotective agent; however, it has low oral...

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Bibliographic Details
Main Authors: Jun Liang, Ying Liu, Jinguang Liu, Zhe Li, Qiangyuan Fan, Zifei Jiang, Fei Yan, Zhi Wang, Peiwen Huang, Nianping Feng
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Nanobiotechnology
Subjects:
Chitosan-functioned lipid-polymer hybrid nanoparticle
Silymarin
Oral bioavailability
Lipid-lowering effect
Non-alcoholic fatty liver disease
Online Access:http://link.springer.com/article/10.1186/s12951-018-0391-9

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