IRE1α Expedites the Progression of Castration-Resistant Prostate Cancers via the Positive Feedback Loop of IRE1α/IL-6/AR

IRE1α Expedites the Progression of Castration-Resistant Prostate Cancers via the Positive Feedback Loop of IRE1α/IL-6/AR

Castration-resistant prostate cancer (CRPC) is the lethal form of prostate cancer (PCa), and the underlying molecular mechanism has not been fully elucidated. Inositol requiring enzyme 1 alpha (IRE1α), a key regulator of unfolded protein response (UPR), is intimately associated with PCa progression....

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Bibliographic Details
Main Authors: Fan Yang, Chong Yuan, Dan Wu, Jing Zhang, Xingchun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
castration-resistant prostate cancer
IRE1α
IL-6
androgen receptor
positive-feedback loop
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.671141/full

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