Differential effects of type 1 diabetes mellitus and subsequent osteoblastic β-catenin activation on trabecular and cortical bone in a mouse model
Diabetes: Bone types respond differently to potential intervention Activation of a key signaling pathway implicated in bone mass maintenance helps boost the strength of spongy internal bone in a mouse model of type 1 diabetes mellitus (T1DM) but also increases the porosity of the outer surface, comp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-12-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0186-y |
| Summary: | Diabetes: Bone types respond differently to potential intervention Activation of a key signaling pathway implicated in bone mass maintenance helps boost the strength of spongy internal bone in a mouse model of type 1 diabetes mellitus (T1DM) but also increases the porosity of the outer surface, compromising bone integrity. Zhaowen Zong and colleagues from the Army Medical University in ChongQing, China experimentally induced T1DM in mice and saw greater loss of inner ‘trabecular’ bone than outer ‘cortical’ bone. Looking to improve bone strength, the researchers genetically activated a key signaling pathway by boosting β-catenin levels in bone-forming osteoblast cells. This intervention had different effects on the two bone types, with increased mass and strength in trabecular bone but increased porosity and fragility in cortical bone. The findings offer a cautionary note that therapeutically elevating WNT/β-catenin signaling may not enhance overall bone function in patients with T1DM. |
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| ISSN: | 1226-3613 2092-6413 |