Peptide Self-Assembly Is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives

Peptide Self-Assembly Is Linked to Antibacterial, but Not Antifungal, Activity of Histatin 5 Derivatives

Antimicrobial peptides are important modulators of host defense against bacterial, fungal, and viral pathogens in humans and other multicellular organisms. Two converging paradigms point to a link between antimicrobial peptides that self-assemble into amyloid-like nanoassemblies and classical amyloi...

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Bibliographic Details
Main Authors: Lee Schnaider, Alexander Rosenberg, Topaz Kreiser, Sofiya Kolusheva, Ehud Gazit, Judith Berman
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSphere
Subjects:
antimicrobial peptides
histatins
membrane interactions
self-assembly
Online Access:https://doi.org/10.1128/mSphere.00021-20

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