CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers

Abstract Background Multiple factors, including co-exposure between lifestyle and environmental risks, are important in susceptibility to oxidative DNA damage. However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methyla...

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Bibliographic Details
Main Authors: Yanli Liu, Xuejing Li, Bin Zhang, Ye Fu, Aimin Yang, Hongjie Zhang, Huitao Zhang, Yingying Niu, Jisheng Nie, Jin Yang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Environmental Health
Subjects:
Oxidative DNA damage
Polycyclic aromatic hydrocarbons
Smoking
Cytochrome P4501A1
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12940-019-0508-0

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