Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.

These studies examine the regulation of plasma low density lipoprotein (LDL)-cholesterol levels by varying quantities of dietary saturated and polyunsaturated triacylglycerols. At a constant load of 0.12% cholesterol and 20% triacylglycerol, substitution of polyunsaturated for saturated triacylglyce...

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Main Authors: LA Woollett, DK Spady, JM Dietschy
Format: Article
Language:English
Published: Elsevier 1992-01-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418851
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spelling doaj-e73c902ab1a14393b648238491b4b43d2021-04-26T05:53:12ZengElsevierJournal of Lipid Research0022-22751992-01-013317788Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.LA Woollett0DK Spady1JM Dietschy2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8887.Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8887.Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8887.These studies examine the regulation of plasma low density lipoprotein (LDL)-cholesterol levels by varying quantities of dietary saturated and polyunsaturated triacylglycerols. At a constant load of 0.12% cholesterol and 20% triacylglycerol, substitution of polyunsaturated for saturated triacylglycerols caused LDL receptor activity to increase from 25% to 80% of control and reduced the LDL-cholesterol production rate from nearly 200% to 155%. These changes caused the plasma LDL-cholesterol concentration to decrease from nearly 190 to 50 mg/dl. When the dietary content of each triacylglycerol alone was incrementally increased, the saturated lipid suppressed receptor activity while the polyunsaturated triacylglycerol increased receptor-dependent LDL transport. The magnitude of these effects was quantitatively similar, although oppositely directed. However, the saturated triacylglycerol also caused a dose-dependent increase in the LDL-cholesterol production rate and markedly increased the plasma LDL-cholesterol level while the polyunsaturated lipid did not affect either of these. These independent effects were also evident in experiments where it was found that substituting polyunsaturated triacylglycerol for saturated lipid increased receptor activity significantly more than did simply reducing the dietary content of saturated triacylglycerol. Thus, these studies show that triacylglycerols containing saturated or polyunsaturated fatty acids have effects on the major processes that regulate the plasma LDL-cholesterol level that are qualitatively and quantitatively distinct.http://www.sciencedirect.com/science/article/pii/S0022227520418851
collection DOAJ
language English
format Article
sources DOAJ
author LA Woollett
DK Spady
JM Dietschy
spellingShingle LA Woollett
DK Spady
JM Dietschy
Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
Journal of Lipid Research
author_facet LA Woollett
DK Spady
JM Dietschy
author_sort LA Woollett
title Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
title_short Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
title_full Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
title_fullStr Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
title_full_unstemmed Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
title_sort saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 1992-01-01
description These studies examine the regulation of plasma low density lipoprotein (LDL)-cholesterol levels by varying quantities of dietary saturated and polyunsaturated triacylglycerols. At a constant load of 0.12% cholesterol and 20% triacylglycerol, substitution of polyunsaturated for saturated triacylglycerols caused LDL receptor activity to increase from 25% to 80% of control and reduced the LDL-cholesterol production rate from nearly 200% to 155%. These changes caused the plasma LDL-cholesterol concentration to decrease from nearly 190 to 50 mg/dl. When the dietary content of each triacylglycerol alone was incrementally increased, the saturated lipid suppressed receptor activity while the polyunsaturated triacylglycerol increased receptor-dependent LDL transport. The magnitude of these effects was quantitatively similar, although oppositely directed. However, the saturated triacylglycerol also caused a dose-dependent increase in the LDL-cholesterol production rate and markedly increased the plasma LDL-cholesterol level while the polyunsaturated lipid did not affect either of these. These independent effects were also evident in experiments where it was found that substituting polyunsaturated triacylglycerol for saturated lipid increased receptor activity significantly more than did simply reducing the dietary content of saturated triacylglycerol. Thus, these studies show that triacylglycerols containing saturated or polyunsaturated fatty acids have effects on the major processes that regulate the plasma LDL-cholesterol level that are qualitatively and quantitatively distinct.
url http://www.sciencedirect.com/science/article/pii/S0022227520418851
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