Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway

Abstract Background Remote ischemic preconditioning (RIPC) initiates endogenous protective pathways in the brain from a distance and represents a new, promising paradigm in neuroprotection against cerebral ischemia-reperfusion (I/R) injury. However, the underlying mechanism of RIPC-mediated cerebral...

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Bibliographic Details
Main Authors: Weidong Liang, Chunshui Lin, Liuqing Yuan, Li Chen, Peipei Guo, Ping Li, Wei Wang, Xin Zhang
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Neuroinflammation
Subjects:
Ischemia-reperfusion injury
Remote ischemic preconditioning
Neuroprotection
Notch1 pathway
NF-kappa B
Cross reaction
Online Access:http://link.springer.com/article/10.1186/s12974-019-1570-9

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