Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study

• Main Authors: Yuji Shimizu, Hirotomo Yamanashi, Masayasu Kitamura, Reiko Furugen, Takahiro Iwasaki, Hideki Fukuda, Hideaki Hayashida, Koji Kawasaki, Kairi Kiyoura, Shin-Ya Kawashiri, Toshiyuki Saito, Atsushi Kawakami, Takahiro Maeda
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: Environmental Health and Preventive Medicine
• Subjects: Elderly participants; Hematopoietic activity; HTLV-1; Periodontitis; Reticulocyte
• Online Access: http://link.springer.com/article/10.1186/s12199-019-0796-6
• ISSN: 1342-078X; 1347-4715

Abstract Background We reported that human T cell leukemia virus 1 (HTLV-1) infection is positively associated with atherosclerosis. Recent evidence has revealed a close association of periodontitis with atherosclerosis, endothelial dysfunction, and disruption of the microcirculation. However, the association between HTLV-1 and advanced periodontitis has not been investigated to date. Since hematopoietic activity is closely linked to endothelial maintenance activity and is known to decline with age, we hypothesized that the state of hematopoietic activity influenced the association between HTLV-1 and advanced periodontitis in elderly participants. Methods A cross-sectional study was performed including 822 elderly participants aged 60–99 years who participated in a dental health check-up. Advanced periodontitis was defined as a periodontal pocket ≥ 6.0 mm. Participants were classified as having low or high hematopoietic activity according to the median values of reticulocytes. Results HTLV-1 infection was positively related to advanced periodontitis among participants with lower hematopoietic activity (lower reticulocyte count), but not among participants with higher hematopoietic activity (higher reticulocyte count). The adjusted odds ratio (95% confidence interval) considering potential confounding factors was 1.92 (1.05–3.49) for participants with a lower reticulocyte count and 0.69 (0.35–1.36) for participants with a higher reticulocyte count. Conclusions Among elderly participants, the association between HTLV-1 infection and advanced periodontitis is influenced by hematopoietic activity. Since hematopoietic activity is associated with endothelial maintenance, these findings provide an efficient tool for clarifying the underlying mechanism of the progression of periodontitis among elderly participants.