Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in hum...

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Main Authors: Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20145-9
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spelling doaj-e72a170c1c0d4aa795c47a4475b866292021-01-31T12:59:18ZengNature Publishing GroupNature Communications2041-17232020-12-0111111110.1038/s41467-020-20145-9Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydrataseGang Liu0Debangsu Sil1Nunziata Maio2Wing-Hang Tong3J. Martin Bollinger4Carsten Krebs5Tracey Ann Rouault6Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthDepartment of Chemistry, The Pennsylvania State UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthDepartment of Chemistry, The Pennsylvania State UniversityDepartment of Chemistry, The Pennsylvania State UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthHeme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in human cells.https://doi.org/10.1038/s41467-020-20145-9
collection DOAJ
language English
format Article
sources DOAJ
author Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
spellingShingle Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
Nature Communications
author_facet Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
author_sort Gang Liu
title Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_short Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_full Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_fullStr Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_full_unstemmed Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_sort heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-12-01
description Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in human cells.
url https://doi.org/10.1038/s41467-020-20145-9
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AT nunziatamaio hemebiosynthesisdependsonpreviouslyunrecognizedacquisitionofironsulfurcofactorsinhumanaminolevulinicaciddehydratase
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