Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress

Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress

The NAD+-dependent deacetylases Sirt1 and Sirt2 mediate cellular stress responses and are highly expressed in vascular endothelial cells. In contrast to the well-documented protective actions of Sirt1, the role of endothelial Sirt2 remains unknown. Using cDNA microarray and PCR validation, we examin...

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Bibliographic Details
Main Authors: Qunye Zhang, Fan Jiang, Peili Bu, Yun Zhang, Xi Wang, Xiao Wu, Junni Liu
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:International Journal of Molecular Sciences
Subjects:
Sirt1
Sirt2
endothelial cell
oxidative stress
functional genomics
microarray
Online Access:http://www.mdpi.com/1422-0067/14/3/5633

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