Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.

Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.

TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5'-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3....

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Main Authors: Rossana Cocchiola, Caterina Grillo, Fabio Altieri, Silvia Chichiarelli, Carlo Turano, Margherita Eufemi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4234655?pdf=render
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spelling doaj-e71f5443c102412d85f5839da53fcc542020-11-25T02:23:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11309610.1371/journal.pone.0113096Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.Rossana CocchiolaCaterina GrilloFabio AltieriSilvia ChichiarelliCarlo TuranoMargherita EufemiTPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5'-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A specific STAT3 peptide inhibitor represses the expression of the Tpx2 gene and inhibits the binding of STAT3 to its consensus sequence in human cell lines where STAT3 is activated. These results indicate that activated STAT3 contributes to the over-expression of Tpx2 through the binding to an enhancer site.http://europepmc.org/articles/PMC4234655?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Rossana Cocchiola
Caterina Grillo
Fabio Altieri
Silvia Chichiarelli
Carlo Turano
Margherita Eufemi
spellingShingle Rossana Cocchiola
Caterina Grillo
Fabio Altieri
Silvia Chichiarelli
Carlo Turano
Margherita Eufemi
Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
PLoS ONE
author_facet Rossana Cocchiola
Caterina Grillo
Fabio Altieri
Silvia Chichiarelli
Carlo Turano
Margherita Eufemi
author_sort Rossana Cocchiola
title Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
title_short Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
title_full Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
title_fullStr Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
title_full_unstemmed Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
title_sort upregulation of tpx2 by stat3: identification of a novel stat3 binding site.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description TPX2, a protein involved in mitosis, is considered a good marker for actively proliferating tissues, highly expressed in a number of cancer cells. We show the presence of high-affinity binding site for STAT3 in the 5'-flanking region of the Tpx2 gene, which is in vivo bound by activated STAT3. A specific STAT3 peptide inhibitor represses the expression of the Tpx2 gene and inhibits the binding of STAT3 to its consensus sequence in human cell lines where STAT3 is activated. These results indicate that activated STAT3 contributes to the over-expression of Tpx2 through the binding to an enhancer site.
url http://europepmc.org/articles/PMC4234655?pdf=render
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AT caterinagrillo upregulationoftpx2bystat3identificationofanovelstat3bindingsite
AT fabioaltieri upregulationoftpx2bystat3identificationofanovelstat3bindingsite
AT silviachichiarelli upregulationoftpx2bystat3identificationofanovelstat3bindingsite
AT carloturano upregulationoftpx2bystat3identificationofanovelstat3bindingsite
AT margheritaeufemi upregulationoftpx2bystat3identificationofanovelstat3bindingsite
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