In vivo reprogramming drives Kras-induced cancer development
Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04449-5 |
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doaj-e71dfb2ea18648a280e79553208854332021-05-11T10:23:26ZengNature Publishing GroupNature Communications2041-17232018-05-019111610.1038/s41467-018-04449-5In vivo reprogramming drives Kras-induced cancer developmentHirofumi Shibata0Shingo Komura1Yosuke Yamada2Nao Sankoda3Akito Tanaka4Tomoyo Ukai5Mio Kabata6Satoko Sakurai7Bunya Kuze8Knut Woltjen9Hironori Haga10Yatsuji Ito11Yoshiya Kawaguchi12Takuya Yamamoto13Yasuhiro Yamada14Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Otolaryngology, Gifu University Graduate School of MedicineDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Diagnostic Pathology, Kyoto University HospitalDepartment of Otolaryngology, Gifu University Graduate School of MedicineDepartment of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto UniversityCellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.https://doi.org/10.1038/s41467-018-04449-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hirofumi Shibata Shingo Komura Yosuke Yamada Nao Sankoda Akito Tanaka Tomoyo Ukai Mio Kabata Satoko Sakurai Bunya Kuze Knut Woltjen Hironori Haga Yatsuji Ito Yoshiya Kawaguchi Takuya Yamamoto Yasuhiro Yamada |
| spellingShingle |
Hirofumi Shibata Shingo Komura Yosuke Yamada Nao Sankoda Akito Tanaka Tomoyo Ukai Mio Kabata Satoko Sakurai Bunya Kuze Knut Woltjen Hironori Haga Yatsuji Ito Yoshiya Kawaguchi Takuya Yamamoto Yasuhiro Yamada In vivo reprogramming drives Kras-induced cancer development Nature Communications |
| author_facet |
Hirofumi Shibata Shingo Komura Yosuke Yamada Nao Sankoda Akito Tanaka Tomoyo Ukai Mio Kabata Satoko Sakurai Bunya Kuze Knut Woltjen Hironori Haga Yatsuji Ito Yoshiya Kawaguchi Takuya Yamamoto Yasuhiro Yamada |
| author_sort |
Hirofumi Shibata |
| title |
In vivo reprogramming drives Kras-induced cancer development |
| title_short |
In vivo reprogramming drives Kras-induced cancer development |
| title_full |
In vivo reprogramming drives Kras-induced cancer development |
| title_fullStr |
In vivo reprogramming drives Kras-induced cancer development |
| title_full_unstemmed |
In vivo reprogramming drives Kras-induced cancer development |
| title_sort |
in vivo reprogramming drives kras-induced cancer development |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-05-01 |
| description |
Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development. |
| url |
https://doi.org/10.1038/s41467-018-04449-5 |
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