Structural adaptation and heterogeneity of normal and tumor microvascular networks.

Structural adaptation and heterogeneity of normal and tumor microvascular networks.

Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel structural adaptation are used to explore the hypothesis that abnormal adaptive respon...

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Bibliographic Details
Main Authors: Axel R Pries, Annemiek J M Cornelissen, Anoek A Sloot, Marlene Hinkeldey, Matthew R Dreher, Michael Höpfner, Mark W Dewhirst, Timothy W Secomb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2682204?pdf=render

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