The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy

The Molecular Basis of Ubiquitin-Conjugating Enzymes (E2s) as a Potential Target for Cancer Therapy

Ubiquitin-conjugating enzymes (E2s) are one of the three enzymes required by the ubiquitin-proteasome pathway to connect activated ubiquitin to target proteins via ubiquitin ligases. E2s determine the connection type of the ubiquitin chains, and different types of ubiquitin chains regulate the stabi...

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Bibliographic Details
Main Authors: Xiaodi Du, Hongyu Song, Nengxing Shen, Ruiqi Hua, Guangyou Yang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquitin-conjugating enzymes
E2s
cancer
target
NF-κB
inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/7/3440

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