Renal Inflammation and Innate Immune Activation Underlie the Transition From Gentamicin-Induced Acute Kidney Injury to Renal Fibrosis

Renal Inflammation and Innate Immune Activation Underlie the Transition From Gentamicin-Induced Acute Kidney Injury to Renal Fibrosis

Subjects recovering from acute kidney injury (AKI) are at risk of developing chronic kidney disease (CKD). The mechanisms underlying this transition are unclear and may involve sustained activation of renal innate immunity, with resulting renal inflammation and fibrosis. We investigated whether the...

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Bibliographic Details
Main Authors: Amanda Helen Albino, Fernanda Florencia Fregnan Zambom, Orestes Foresto-Neto, Karin Carneiro Oliveira, Victor Ferreira Ávila, Simone Costa Alarcon Arias, Antonio Carlos Seguro, Denise Maria Avancini Costa Malheiros, Niels Olsen Saraiva Camara, Clarice Kazue Fujihara, Roberto Zatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
acute kidney injury
chronic kidney disease
gentamicin
innate immunity
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.606392/full

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