Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

• Main Authors: Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung
• Format: Article
• Language: English
• Published: MDPI AG 2021-05-01
• Series: Marine Drugs
• Subjects: marine organisms; polydeoxyribonucleotide; biomedical engineering
• Online Access: https://www.mdpi.com/1660-3397/19/6/296

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A_2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.