Blocking DNA Damage Repair May Be Involved in Stattic (STAT3 Inhibitor)-Induced FLT3-ITD AML Cell Apoptosis

Blocking DNA Damage Repair May Be Involved in Stattic (STAT3 Inhibitor)-Induced FLT3-ITD AML Cell Apoptosis

The FMS-like tyrosine kinase 3 (FLT3)- internal tandem duplication (ITD) mutation can be found in approximately 25% of all acute myeloid leukemia (AML) cases and is associated with a poor prognosis. The main treatment for FLT3-ITD-positive AML patients includes genotoxic therapy and FLT3 inhibitors,...

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Bibliographic Details
Main Authors: Yuxuan Luo, Ying Lu, Bing Long, Yansi Lin, Yanling Yang, Yichuang Xu, Xiangzhong Zhang, Jingwen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
FLT3-ITD mutation
acute myeloid leukemia
DNA damage repair
apoptosis
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.637064/full

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