In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturatio...

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Bibliographic Details
Main Authors: Jiying Ning, Gonca Erdemci-Tandogan, Ernest L. Yufenyuy, Jef Wagner, Benjamin A. Himes, Gongpu Zhao, Christopher Aiken, Roya Zandi, Peijun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13689
Description
Summary:Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturation process.
ISSN:2041-1723

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