Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force

Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force

Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several...

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Main Authors: Clémence Vigouroux, Véronique Henriot, Christophe Le Clainche
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16922-1
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spelling doaj-e6f4002112094dafbff45c5811349b882021-06-20T11:15:14ZengNature Publishing GroupNature Communications2041-17232020-06-0111111110.1038/s41467-020-16922-1Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin forceClémence Vigouroux0Véronique Henriot1Christophe Le Clainche2Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several talin domains.https://doi.org/10.1038/s41467-020-16922-1
collection DOAJ
language English
format Article
sources DOAJ
author Clémence Vigouroux
Véronique Henriot
Christophe Le Clainche
spellingShingle Clémence Vigouroux
Véronique Henriot
Christophe Le Clainche
Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
Nature Communications
author_facet Clémence Vigouroux
Véronique Henriot
Christophe Le Clainche
author_sort Clémence Vigouroux
title Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_short Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_full Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_fullStr Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_full_unstemmed Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
title_sort talin dissociates from riam and associates to vinculin sequentially in response to the actomyosin force
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Force-dependent formation of the talin-vinculin complex reinforces actin anchoring to focal adhesions, but how different talin-binding proteins respond to force is unclear. Here authors use an in vitro microscopy assay and show that the actomyosin force triggers the dissociation of RIAM from several talin domains.
url https://doi.org/10.1038/s41467-020-16922-1
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AT veroniquehenriot talindissociatesfromriamandassociatestovinculinsequentiallyinresponsetotheactomyosinforce
AT christopheleclainche talindissociatesfromriamandassociatestovinculinsequentiallyinresponsetotheactomyosinforce
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