Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression

Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression

Background: Stereotactic radiotherapy treats hepatocellular carcinoma (HCC) at different stages effectively and safely. Besides its direct killing of cancer cells, radiotherapy stimulates host immunity against hepatoma. However, the role of myeloid-derived suppressor cells (MDSCs) in on-target and o...

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Bibliographic Details
Main Authors: Junying Chen, Zeng Wang, Yuxiong Ding, Fei Huang, Weikang Huang, Ruilong Lan, Ruiqing Chen, Bing Wu, Lengxi Fu, Yunhua Yang, Jun Liu, Jinsheng Hong, Weijian Zhang, Lurong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
in situ tumor vaccine
high-dose low-fraction radiation
myeloid-derived suppressor cells
negative immune breaker
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00004/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00004/full

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