Cancer research and therapy: Where are we today?

<p>Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms. Certain special features of cancer cells enable researchers to deliver the...

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Main Authors: Sampada Sawant, Ranjita Shegokar
Format: Article
Language:English
Published: IJCTO 2014-12-01
Series:International Journal of Cancer Therapy and Oncology
Subjects:
Online Access:http://ijcto.org/index.php/IJCTO/article/view/153
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spelling doaj-e6eb32ca8ae94ab9930deb5d9e4c41792020-11-24T22:44:11ZengIJCTOInternational Journal of Cancer Therapy and Oncology 2330-40492014-12-012410.14319/ijcto.0204.8122Cancer research and therapy: Where are we today?Sampada Sawant0Ranjita Shegokar1C.U. Shah College of Pharmacy, SNDT Women’s University, Juhu, Santacruz (West), Mumbai, IndiaDepartment of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universität Berlin, Berlin, Germany<p>Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms. Certain special features of cancer cells enable researchers to deliver the drug or to develop the right drug therapy. These cell properties include over expression or over activity in uptake of certain nutrients e.g. folic acid and increased permeability. Listed properties might vary depending upon the type of cancer and can be fully exploited by using nanoparticles either to detect the site of cancer or to direct the drug at the affected site. Product approach like drug conjugates, complexes serves as a good platform to solve issues like solubility, toxicity, poor penetration and stability related to cancer drugs. Beside this, several drug delivery platforms are under development by researchers in academia as well as in industry to deliver therapeutic molecules and new chemical entities to the targeted site in body. Amongst them, nanotechnology both at molecular and supramolecular level is a leading platform and can help to image, detect and treat cancer. Surface modification of nanoparticles by coating or anchoring their surface with special markers, materials, peptide, proteins, antibodies or antigens add extra feature and thereby can enhance the effectiveness. These treatments can be used individually or in combined form. In this review, advances on nanotechnological platform are discussed together with some assisting techniques like magnetic field, photo or light field, sonic rays are touched upon. New biological therapies that are advancing in this direction include the antisense therapy, cell therapy, gene therapy, radiation therapy and SiRNA interfaces which are discussed in brief in this article. This article gives short overview on use of complementary and alternative medicine for treatment of cancer such as traditional Chinese medicine (TCM), Ayurveda to avoid toxic effects of synthetic drugs.</p>http://ijcto.org/index.php/IJCTO/article/view/153Cancer TherapyNanoparticlesTargeting DrugsSurface ModificationGene TherapyVaccinesHerbal ActivesPersonalized Medicine
collection DOAJ
language English
format Article
sources DOAJ
author Sampada Sawant
Ranjita Shegokar
spellingShingle Sampada Sawant
Ranjita Shegokar
Cancer research and therapy: Where are we today?
International Journal of Cancer Therapy and Oncology
Cancer Therapy
Nanoparticles
Targeting Drugs
Surface Modification
Gene Therapy
Vaccines
Herbal Actives
Personalized Medicine
author_facet Sampada Sawant
Ranjita Shegokar
author_sort Sampada Sawant
title Cancer research and therapy: Where are we today?
title_short Cancer research and therapy: Where are we today?
title_full Cancer research and therapy: Where are we today?
title_fullStr Cancer research and therapy: Where are we today?
title_full_unstemmed Cancer research and therapy: Where are we today?
title_sort cancer research and therapy: where are we today?
publisher IJCTO
series International Journal of Cancer Therapy and Oncology
issn 2330-4049
publishDate 2014-12-01
description <p>Till date scientists are struggling to understand the complete mechanism of carcinogenesis. In future, the real time detection of cancer may help scientists to identify some of the complicated biological mechanisms. Certain special features of cancer cells enable researchers to deliver the drug or to develop the right drug therapy. These cell properties include over expression or over activity in uptake of certain nutrients e.g. folic acid and increased permeability. Listed properties might vary depending upon the type of cancer and can be fully exploited by using nanoparticles either to detect the site of cancer or to direct the drug at the affected site. Product approach like drug conjugates, complexes serves as a good platform to solve issues like solubility, toxicity, poor penetration and stability related to cancer drugs. Beside this, several drug delivery platforms are under development by researchers in academia as well as in industry to deliver therapeutic molecules and new chemical entities to the targeted site in body. Amongst them, nanotechnology both at molecular and supramolecular level is a leading platform and can help to image, detect and treat cancer. Surface modification of nanoparticles by coating or anchoring their surface with special markers, materials, peptide, proteins, antibodies or antigens add extra feature and thereby can enhance the effectiveness. These treatments can be used individually or in combined form. In this review, advances on nanotechnological platform are discussed together with some assisting techniques like magnetic field, photo or light field, sonic rays are touched upon. New biological therapies that are advancing in this direction include the antisense therapy, cell therapy, gene therapy, radiation therapy and SiRNA interfaces which are discussed in brief in this article. This article gives short overview on use of complementary and alternative medicine for treatment of cancer such as traditional Chinese medicine (TCM), Ayurveda to avoid toxic effects of synthetic drugs.</p>
topic Cancer Therapy
Nanoparticles
Targeting Drugs
Surface Modification
Gene Therapy
Vaccines
Herbal Actives
Personalized Medicine
url http://ijcto.org/index.php/IJCTO/article/view/153
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