Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation
The preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been prop...
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2012-08-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/867 |
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doaj-e6d8284b8d104fa7b731260cd55d2d532021-07-22T07:51:34ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2012-08-0104(114)333510.21055/0370-1069-2012-4-33-35851Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine PreparationD. A. Budyka0A. I. Bondarenko1A. A. Fisun2N. V. Abzaeva3G. F. Ivanova4S. E. Gostishcheva5S. M. Rudnev6Stavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteStavropol Research Anti-Plague InstituteThe preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been proposed. This interpretation stipulates a smaller damaging effect of steam molecules during sublimation in the process of lyophilization.https://journal.microbe.ru/jour/article/view/867температурный режимвакцина чумная живаяпараметры качества готового препаратаэлектронная микроскопияморфология клеткилиофилизацияtemperature conditionlive plague vaccinequality parameters of stock-produced preparationelectron microscopycell morphologylyophilization |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
D. A. Budyka A. I. Bondarenko A. A. Fisun N. V. Abzaeva G. F. Ivanova S. E. Gostishcheva S. M. Rudnev |
| spellingShingle |
D. A. Budyka A. I. Bondarenko A. A. Fisun N. V. Abzaeva G. F. Ivanova S. E. Gostishcheva S. M. Rudnev Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation Проблемы особо опасных инфекций температурный режим вакцина чумная живая параметры качества готового препарата электронная микроскопия морфология клетки лиофилизация temperature condition live plague vaccine quality parameters of stock-produced preparation electron microscopy cell morphology lyophilization |
| author_facet |
D. A. Budyka A. I. Bondarenko A. A. Fisun N. V. Abzaeva G. F. Ivanova S. E. Gostishcheva S. M. Rudnev |
| author_sort |
D. A. Budyka |
| title |
Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation |
| title_short |
Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation |
| title_full |
Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation |
| title_fullStr |
Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation |
| title_full_unstemmed |
Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation |
| title_sort |
qualitative indicators of microbial cells of yersinia pestis ev strain depending on their morphological traits in different temperature conditions of manufacturing of plague vaccine preparation |
| publisher |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| series |
Проблемы особо опасных инфекций |
| issn |
0370-1069 2658-719X |
| publishDate |
2012-08-01 |
| description |
The preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been proposed. This interpretation stipulates a smaller damaging effect of steam molecules during sublimation in the process of lyophilization. |
| topic |
температурный режим вакцина чумная живая параметры качества готового препарата электронная микроскопия морфология клетки лиофилизация temperature condition live plague vaccine quality parameters of stock-produced preparation electron microscopy cell morphology lyophilization |
| url |
https://journal.microbe.ru/jour/article/view/867 |
| work_keys_str_mv |
AT dabudyka qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT aibondarenko qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT aafisun qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT nvabzaeva qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT gfivanova qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT segostishcheva qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation AT smrudnev qualitativeindicatorsofmicrobialcellsofyersiniapestisevstraindependingontheirmorphologicaltraitsindifferenttemperatureconditionsofmanufacturingofplaguevaccinepreparation |
| _version_ |
1721291914226958336 |