First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides.

First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides.

The main control strategy for Ascaris lumbricoides is mass drug administration (especially with benzimidazoles), which can select strains of parasites resistant to treatment. Mutations in the beta-tubulin isotype-1 gene at codons 167, 198 and 200 have been linked to benzimidazole resistance in sever...

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Main Authors: Luis Fernando Viana Furtado, Celi da Silva Medeiros, Luciana Werneck Zuccherato, William Pereira Alves, Valéria Nayara Gomes Mendes de Oliveira, Vivian Jordania da Silva, Guilherme Silva Miranda, Ricardo Toshio Fujiwara, Élida Mara Leite Rabelo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224108

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