Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor
Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic parave...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-04-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2019-0010 |
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doaj-e6c8a6dc6d644cc39b5a0970b4c23c842021-09-05T21:00:49ZengSciendoEndocrine Regulations1336-03292019-04-01532839210.2478/enr-2019-0010enr-2019-0010Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressorOsacka Jana0Horvathova Lubica1Cernackova Alena2Kiss Alexander3Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, SlovakiaObjective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic paraventricular nucleus (PVN). Some of these regions are known to be also stress responsive. This study was designed to determine whether repeated clozapine (CLZ) administration for 7 consecutive days to Wistar rats may modify FosB/ΔFosB expression in the above-mentioned brain areas induced by acute stress or novel stressor that followed 13-day chronic mild stress preconditioning.https://doi.org/10.2478/enr-2019-0010clozapineacute and novel stresschronic mild stressfosb/δfosbforebrain |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander |
| spellingShingle |
Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor Endocrine Regulations clozapine acute and novel stress chronic mild stress fosb/δfosb forebrain |
| author_facet |
Osacka Jana Horvathova Lubica Cernackova Alena Kiss Alexander |
| author_sort |
Osacka Jana |
| title |
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor |
| title_short |
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor |
| title_full |
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor |
| title_fullStr |
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor |
| title_full_unstemmed |
Clozapine impact on FosB/ΔFosB expression in stress preconditioned rats: response to a novel stressor |
| title_sort |
clozapine impact on fosb/δfosb expression in stress preconditioned rats: response to a novel stressor |
| publisher |
Sciendo |
| series |
Endocrine Regulations |
| issn |
1336-0329 |
| publishDate |
2019-04-01 |
| description |
Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus accumbens shell and core, and the hypothalamic paraventricular nucleus (PVN). Some of these regions are known to be also stress responsive. This study was designed to determine whether repeated clozapine (CLZ) administration for 7 consecutive days to Wistar rats may modify FosB/ΔFosB expression in the above-mentioned brain areas induced by acute stress or novel stressor that followed 13-day chronic mild stress preconditioning. |
| topic |
clozapine acute and novel stress chronic mild stress fosb/δfosb forebrain |
| url |
https://doi.org/10.2478/enr-2019-0010 |
| work_keys_str_mv |
AT osackajana clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT horvathovalubica clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT cernackovaalena clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor AT kissalexander clozapineimpactonfosbdfosbexpressioninstresspreconditionedratsresponsetoanovelstressor |
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1717782219896913920 |