CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A

The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in neuroblastic-type NB cells by increasing the acetylation of Ku70, a Bax-binding protein. Ku70 acetylation causes Bax release and activation...

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Bibliographic Details
Main Authors: Chitra Subramanian, Jason A. Jarzembowski, Anthony W. Opipari, Jr., Valerie P. Castle, Roland P.S. Kwok
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Histone acetyltransferase
histone deacetylase
Ku70
Bax
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800066

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