Investigation protective effects of vitamin E against mobile radiations induced histological alterations and oxidative stress in rats’ brain

• Main Authors: Hanieh Saramad, Farah Farokhi, Gholamreza Najafi, Ali Shalizar jalali
• Format: Article
• Language: fas
• Published: Shahid Sadoughi University of Medical Sciences 2018-01-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
• Subjects: Brain; hippocampus; Mobile Radiation; Rat; Vitamin E.
• Online Access: http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3326-1&slc_lang=en&sid=1
• ISSN: 2228-5741; 2228-5733

Introduction: It has been shown that mobile radiations (MRs) have detrimental effects on brain histoarchitecture and vitamin E as a powerful antioxidant can exhibit neuroprotective effects. This study was carried out to evaluate the protective effects of vitamin E against MRs-induced histological changes in rat brain. Methods: Adult female Wistar rats were randomly categorized into 4 groups (n₌6), including untreated control, experimental group1 (14 days exposure to mobile calls, 12 times every day and each time for 10 minutes by Huawei H30–U10 cell phone and then, sampling on day 15), experimental group2 (14 days treatment and then, sampling after 40 days) and experimental group3 (radiation + vitamin E 100 mg/kg intramuscularly before MRs exposure). Results: MRS-treatedrats showed significant reduction in body weight with an increase in brain relative weight. Moreover, MRS resulted in oxidative stress in brain tissue as well as increase in numbers of neurons with pyknotic nuclei in rats hippocampus. Interestingly, vitamin E co-administration led to oxidative stress suppression in brain tissue and nuclear pyknosis reduction in rats hippocampus. Conclusion: Vitamin E can attenuate MRs- induced histological alterations and oxidative stress in rat hippocampus probably due to antioxidant activities.