miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability

The evolutionarily conserved miR-302 family of microRNAs is expressed during early mammalian embryonic development. Here, we report that deletion of miR-302a-d in mice results in a fully penetrant late embryonic lethal phenotype. Knockout embryos have an anterior neural tube closure defect associate...

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Bibliographic Details
Main Authors: Ronald J. Parchem, Nicole Moore, Jennifer L. Fish, Jacqueline G. Parchem, Tarcio T. Braga, Archana Shenoy, Michael C. Oldham, John L.R. Rubenstein, Richard A. Schneider, Robert Blelloch
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715007123

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http://www.sciencedirect.com/science/article/pii/S2211124715007123

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