Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway

Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway

In this study, a pair of chiral baicalin (BA) derivatives were synthesized by combining BA with phenylalanine methyl ester based on molecular docking technology, namely BAD and BAL. Cell cytotoxicity trails showed that the cell growth inhibitory effects of both BAD and BAL were increased by 8- to 12...

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Bibliographic Details
Main Authors: Yi Hou, Chao Pi, Xianhu Feng, Yuanyuan Wang, Shaozhi Fu, Xiaomei Zhang, Ling Zhao, Yumeng Wei
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
baicalin
chiral derivatives
PI3K/Akt signaling pathway
apoptosis
lung cancer
molecular docking technology
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301352

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