Immunological imprinting of the antibody response in COVID-19 patients

Immunological imprinting of the antibody response in COVID-19 patients

In addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the i...

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Main Authors: Teresa Aydillo, Alexander Rombauts, Daniel Stadlbauer, Sadaf Aslam, Gabriela Abelenda-Alonso, Alba Escalera, Fatima Amanat, Kaijun Jiang, Florian Krammer, Jordi Carratala, Adolfo García-Sastre
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23977-1
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spelling doaj-e6b17aeb12ca4e21a13051d57fbbeb622021-06-20T11:12:14ZengNature Publishing GroupNature Communications2041-17232021-06-0112111310.1038/s41467-021-23977-1Immunological imprinting of the antibody response in COVID-19 patientsTeresa Aydillo0Alexander Rombauts1Daniel Stadlbauer2Sadaf Aslam3Gabriela Abelenda-Alonso4Alba Escalera5Fatima Amanat6Kaijun Jiang7Florian Krammer8Jordi Carratala9Adolfo García-Sastre10Department of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de LlobregatDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de LlobregatDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Microbiology, Icahn School of Medicine at Mount SinaiDepartment of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de LlobregatDepartment of Microbiology, Icahn School of Medicine at Mount SinaiIn addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the induction of specific antibodies against SARS-CoV-2.https://doi.org/10.1038/s41467-021-23977-1
collection DOAJ
language English
format Article
sources DOAJ
author Teresa Aydillo
Alexander Rombauts
Daniel Stadlbauer
Sadaf Aslam
Gabriela Abelenda-Alonso
Alba Escalera
Fatima Amanat
Kaijun Jiang
Florian Krammer
Jordi Carratala
Adolfo García-Sastre
spellingShingle Teresa Aydillo
Alexander Rombauts
Daniel Stadlbauer
Sadaf Aslam
Gabriela Abelenda-Alonso
Alba Escalera
Fatima Amanat
Kaijun Jiang
Florian Krammer
Jordi Carratala
Adolfo García-Sastre
Immunological imprinting of the antibody response in COVID-19 patients
Nature Communications
author_facet Teresa Aydillo
Alexander Rombauts
Daniel Stadlbauer
Sadaf Aslam
Gabriela Abelenda-Alonso
Alba Escalera
Fatima Amanat
Kaijun Jiang
Florian Krammer
Jordi Carratala
Adolfo García-Sastre
author_sort Teresa Aydillo
title Immunological imprinting of the antibody response in COVID-19 patients
title_short Immunological imprinting of the antibody response in COVID-19 patients
title_full Immunological imprinting of the antibody response in COVID-19 patients
title_fullStr Immunological imprinting of the antibody response in COVID-19 patients
title_full_unstemmed Immunological imprinting of the antibody response in COVID-19 patients
title_sort immunological imprinting of the antibody response in covid-19 patients
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description In addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the induction of specific antibodies against SARS-CoV-2.
url https://doi.org/10.1038/s41467-021-23977-1
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