SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

<p>Abstract</p> <p>Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and related family...

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Bibliographic Details
Main Authors: Lin Douglas I, Barbash Olena, Diehl J Alan
Format: Article
Language:English
Published: BMC 2007-01-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/2/1/2

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