A Review of the Clinical and Therapeutic Implications of Neuropathic Pain

A Review of the Clinical and Therapeutic Implications of Neuropathic Pain

Understanding neuropathic pain presents several challenges, given the various mechanisms underlying its pathophysiological classification and the lack of suitable tools to assess its diagnosis. Furthermore, the response of this pathology to available drugs is still often unpredictable, leaving the t...

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Main Authors: Eleonora Balzani, Andrea Fanelli, Valentina Malafoglia, Michael Tenti, Sara Ilari, Annette Corraro, Carolina Muscoli, William Raffaeli
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
neuropathic pain
pain therapy
tailored therapy
Online Access:https://www.mdpi.com/2227-9059/9/9/1239
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spelling doaj-e6a80131339c43e3a2a0c73d9654c33e2021-09-25T23:46:51ZengMDPI AGBiomedicines2227-90592021-09-0191239123910.3390/biomedicines9091239A Review of the Clinical and Therapeutic Implications of Neuropathic PainEleonora Balzani0Andrea Fanelli1Valentina Malafoglia2Michael Tenti3Sara Ilari4Annette Corraro5Carolina Muscoli6William Raffaeli7Department of Medicine and Surgery, University of Turin, 10124 Torino, ItalyAnesthesia, Intensive Care and Pain Therapy Unit, Department of Emergency and Urgency, Istituto ad Alta Specializzazione Policlinico di Monza, Via Amati 111, 20900 Monza, ItalyISAL Foundation Institute for Research on Pain, 47922 Rimini, ItalyISAL Foundation Institute for Research on Pain, 47922 Rimini, ItalyDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University “Magna Graecia” of Catanzaro, Viale Europa, Loc. Germaneto, 88100 Catanzaro, ItalyFaculty of Social and Behavioural Sciences, Leiden University, 2311 Leiden, The NetherlandsDepartment of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University “Magna Graecia” of Catanzaro, Viale Europa, Loc. Germaneto, 88100 Catanzaro, ItalyISAL Foundation Institute for Research on Pain, 47922 Rimini, ItalyUnderstanding neuropathic pain presents several challenges, given the various mechanisms underlying its pathophysiological classification and the lack of suitable tools to assess its diagnosis. Furthermore, the response of this pathology to available drugs is still often unpredictable, leaving the treatment of neuropathic pain still questionable. In addition, the rise of personalized treatments further extends the ramified classification of neuropathic pain. While a few authors have focused on neuropathic pain clustering, by analyzing, for example, the presence of specific TRP channels, others have evaluated the presence of alterations in microRNAs to find tailored therapies. Thus, this review aims to synthesize the available evidence on the topic from a clinical perspective and provide a list of current demonstrations on the treatment of this disease.https://www.mdpi.com/2227-9059/9/9/1239neuropathic painpain therapytailored therapy
collection DOAJ
language English
format Article
sources DOAJ
author Eleonora Balzani
Andrea Fanelli
Valentina Malafoglia
Michael Tenti
Sara Ilari
Annette Corraro
Carolina Muscoli
William Raffaeli
spellingShingle Eleonora Balzani
Andrea Fanelli
Valentina Malafoglia
Michael Tenti
Sara Ilari
Annette Corraro
Carolina Muscoli
William Raffaeli
A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
Biomedicines
neuropathic pain
pain therapy
tailored therapy
author_facet Eleonora Balzani
Andrea Fanelli
Valentina Malafoglia
Michael Tenti
Sara Ilari
Annette Corraro
Carolina Muscoli
William Raffaeli
author_sort Eleonora Balzani
title A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
title_short A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
title_full A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
title_fullStr A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
title_full_unstemmed A Review of the Clinical and Therapeutic Implications of Neuropathic Pain
title_sort review of the clinical and therapeutic implications of neuropathic pain
publisher MDPI AG
series Biomedicines
issn 2227-9059
publishDate 2021-09-01
description Understanding neuropathic pain presents several challenges, given the various mechanisms underlying its pathophysiological classification and the lack of suitable tools to assess its diagnosis. Furthermore, the response of this pathology to available drugs is still often unpredictable, leaving the treatment of neuropathic pain still questionable. In addition, the rise of personalized treatments further extends the ramified classification of neuropathic pain. While a few authors have focused on neuropathic pain clustering, by analyzing, for example, the presence of specific TRP channels, others have evaluated the presence of alterations in microRNAs to find tailored therapies. Thus, this review aims to synthesize the available evidence on the topic from a clinical perspective and provide a list of current demonstrations on the treatment of this disease.
topic neuropathic pain
pain therapy
tailored therapy
url https://www.mdpi.com/2227-9059/9/9/1239
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