The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin NK 2 receptor antagonist. The aim of the tria...

Full description

Bibliographic Details
Main Authors:	Venessa Schelfhout, Veerle Van De Velde, Carlo Maggi, Romain Pauwels, Guy Joos
Format:	Article
Language:	English
Published:	SAGE Publishing 2009-10-01
Series:	Therapeutic Advances in Respiratory Disease
Online Access:	https://doi.org/10.1177/1753465809349741

Similar Items

Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists
by: Takahiro Tanaka, et al.
Published: (2012-01-01)

A study of NK-3 tachykinin receptors
by: Guard, Steven
Published: (1989)

Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements
by: Dozmorov Igor, et al.
Published: (2007-05-01)

Processing of the tachykinin precursor TAC3 in the human placenta and characterisation of the peptide product, neurokinin B (NKB)
by: Brayley, Kerensa
Published: (2005)

Role of the tachykinin NK<sub>1 </sub>receptor in a murine model of cigarette smoke-induced pulmonary inflammation
by: Brusselle Guy G, et al.
Published: (2009-05-01)

Cytotoxic and apoptotic effects of neurokinin-1 receptor (NK1R) antagonist on multiple myeloma cells
by: Elham Razani, et al.
Published: (2019-12-01)

Cytotoxic and apoptotic effects of neurokinin-1 receptor (NK1R) antagonist on multiple myeloma cells
by: Elham Razani, et al.
Published: (2019-12-01)

Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children
by: Ju Hwan Cho, et al.
Published: (2019-01-01)

Mild respiratory symptoms in asthmatic patients might not be due to bronchoconstriction
by: Tarig H Merghani
Published: (2017-01-01)

Peripheral tachykinins and the NK1 receptor regulate platelet function
by: Jones, Sarah
Published: (2007)

Dietary supplementation for the treatment of hyperpnoea induced bronchoconstriction in physically active asthmatics
by: Williams, N.
Published: (2015)

Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs
by: Winkler, Tilo, et al.
Published: (2018)

Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics
by: Charlène Gadais, et al.
Published: (2021-09-01)

Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
by: Eva Borbély, et al.
Published: (2013-01-01)

Neurokinin-1 Receptor Antagonists against Hepatoblastoma
by: Miguel Muñoz, et al.
Published: (2019-08-01)

Peripheral tachykinins and tachykinin receptors
by: Bell, Nicola Jane
Published: (2005)

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors
by: Paweł K. Halik, et al.
Published: (2020-08-01)

Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.
by: Juan S Osorio-Valencia, et al.
Published: (2018-01-01)

An automated bronchial hyperventilation challenge : The response of asthmatics to eucapnic hyperventilation and exercise and the effects of trachea-noise biofeedback on bronchoconstriction in asthmatics
by: Mussell, M. J.
Published: (1986)

Protective effects of different doses of inhaled fenoterol on methacholine-induced bronchoconstriction in asthmatic children
by: Irma Douglas Gomez, et al.

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs
by: Takahiro Tanaka, et al.
Published: (2012-01-01)

Bidirectional Regulation of Human Colonic Smooth Muscle Contractility by Tachykinin NK2 Receptors
by: Akihiro Nakamura, et al.
Published: (2011-01-01)

Affinity, potency, efficacy, and selectivity of neurokinin A analogs at human recombinant NK2 and NK1 receptors.
by: Nadia M J Rupniak, et al.
Published: (2018-01-01)

The role of NK1 and NK2 neurokinin receptors in the acute and sustained nociceptive activation of dorsal horn neurons
by: Munro, Fiona E.
Published: (1997)

Exercise-induced bronchoconstriction: The effects of montelukast, a leukotriene receptor antagonist
by: James P Kemp
Published: (2009-11-01)

Récepteurs des tachykinines. Caractérisation par les agonistes et les antagonistes
by: Dion, Stéphane
Published: (1985)

EPA/DHA dietary supplementation attenuates exercise-induced bronchoconstriction in physically active asthmatic males
by: Aishwarya Kumar, et al.
Published: (2016-12-01)

Expression of Preprotachykinin-I (PPT-I), Neurokinin-1 (NK-1) and Neurokinin-2 (NK-2) in Breast Cancer Cells Improves Tumor Cell Survival in Bone Marrow in the Early Stage of Metastasis
by: Huilai ZHANG, et al.
Published: (2009-06-01)

The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?
by: Miguel Muñoz, et al.
Published: (2020-09-01)

Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
by: Akhil Hegde, et al.
Published: (2010-01-01)

Capsaicin-Mediated Neurogenic Vasodilatation in Neurokinin-1, NK1, Receptor Knockout Mice
by: A. D. Grant, et al.
Published: (2001-01-01)

Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review
by: Philteos George S, et al.
Published: (2005-06-01)

Neurokinin-1-tachykinin receptor agonist promotes diabetic fracture healing in rats with type 1 diabetes via modulation of Wnt/β-catenin signalling axis
by: Xiaohui Wang, et al.
Published: (2021-04-01)

Substance P and its tachykinin NK1 receptor: a novel neuroprotective target for Parkinson′s disease
by: Emma Thornton, et al.
Published: (2015-01-01)

Identification et caractérisation pharmacologique des sous-types de récepteurs NK-1 et NK-3 des neurokinines
by: Nguyen, Quang Trinh
Published: (1994)

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
by: Jendrik Schöppe, et al.
Published: (2019-01-01)

Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting
by: Navari RM, et al.
Published: (2018-10-01)

The role of neurokinin-1 (substance P) antagonists in the prevention of postoperative nausea and vomiting
by: Dionne Okafor, et al.
Published: (2017-01-01)

The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol.
by: Pia Steensland, et al.
Published: (2010-09-01)

Molecular forms of tachykinins
by: Chambers, J. K.
Published: (1989)