Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug

Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug

A group of cytotoxic half-sandwich iridium(III) complexes with aminomethyl(diphenyl)phosphine derived from fluoroquinolone antibiotics exhibit the ability to (i) accumulate in the nucleus, (ii) induce apoptosis, (iii) activate caspase-3/7 activity, (iv) induce the changes in cell cycle leading to G2...

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Bibliographic Details
Main Authors: Sandra Amanda Kozieł, Monika Katarzyna Lesiów, Daria Wojtala, Edyta Dyguda-Kazimierowicz, Dariusz Bieńko, Urszula Katarzyna Komarnicka
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
arene iridium(III) complexes
fluoroquinolones
DNA-binding studies
protein-binding studies
drug delivery
reactive oxygen species
Online Access:https://www.mdpi.com/1424-8247/14/7/685

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