Sesquiterpenoids from the Herb of Leonurus japonicus

Sesquiterpenoids from the Herb of Leonurus japonicus

Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectr...

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Main Authors: Liang Xiong, Qin-Mei Zhou, Cheng Peng, Xiao-Fang Xie, Li Guo, Xiao-Hong Li, Juan Liu, Zhao-Hua Liu, Ou Dai
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Molecules
Subjects:
Leonurus japonicus
sesquiterpenoids
bioactivities
Online Access:http://www.mdpi.com/1420-3049/18/5/5051
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spelling doaj-e69b1216297548b29dc6e986301ba3a32020-11-25T00:04:06ZengMDPI AGMolecules1420-30492013-04-011855051505810.3390/molecules18055051Sesquiterpenoids from the Herb of Leonurus japonicusLiang XiongQin-Mei ZhouCheng PengXiao-Fang XieLi GuoXiao-Hong LiJuan LiuZhao-Hua LiuOu DaiTwo new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.http://www.mdpi.com/1420-3049/18/5/5051Leonurus japonicussesquiterpenoidsbioactivities
collection DOAJ
language English
format Article
sources DOAJ
author Liang Xiong
Qin-Mei Zhou
Cheng Peng
Xiao-Fang Xie
Li Guo
Xiao-Hong Li
Juan Liu
Zhao-Hua Liu
Ou Dai
spellingShingle Liang Xiong
Qin-Mei Zhou
Cheng Peng
Xiao-Fang Xie
Li Guo
Xiao-Hong Li
Juan Liu
Zhao-Hua Liu
Ou Dai
Sesquiterpenoids from the Herb of Leonurus japonicus
Molecules
Leonurus japonicus
sesquiterpenoids
bioactivities
author_facet Liang Xiong
Qin-Mei Zhou
Cheng Peng
Xiao-Fang Xie
Li Guo
Xiao-Hong Li
Juan Liu
Zhao-Hua Liu
Ou Dai
author_sort Liang Xiong
title Sesquiterpenoids from the Herb of Leonurus japonicus
title_short Sesquiterpenoids from the Herb of Leonurus japonicus
title_full Sesquiterpenoids from the Herb of Leonurus japonicus
title_fullStr Sesquiterpenoids from the Herb of Leonurus japonicus
title_full_unstemmed Sesquiterpenoids from the Herb of Leonurus japonicus
title_sort sesquiterpenoids from the herb of leonurus japonicus
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2013-04-01
description Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
topic Leonurus japonicus
sesquiterpenoids
bioactivities
url http://www.mdpi.com/1420-3049/18/5/5051
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