The rational design of specific peptide inhibitor against p38α MAPK at allosteric-site: a therapeutic modality for HNSCC.

The rational design of specific peptide inhibitor against p38α MAPK at allosteric-site: a therapeutic modality for HNSCC.

p38α is a significant target for drug designing against cancer. The overproduction of p38α MAPK promotes tumorigenesis in head and neck squamous cell carcinoma (HNSCC). The ATP binding and an allosteric site referred as DFG are the key sites of the p38α mitogen activated protein kinase (MAPK) exploi...

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Bibliographic Details
Main Authors: Kamaldeep Gill, Lokesh Nigam, Ratnakar Singh, Suresh Kumar, Naidu Subbarao, Shyam Singh Chauhan, Sharmistha Dey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24983631/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24983631/?tool=EBI

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