Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers

Molecular Selection, Modification and Development of Therapeutic Oligonucleotide Aptamers

Monoclonal antibodies are the dominant agents used in inhibition of biological target molecules for disease therapeutics, but there are concerns of immunogenicity, production, cost and stability. Oligonucleotide aptamers have comparable affinity and specificity to targets with monoclonal antibodies...

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Bibliographic Details
Main Authors: Yuanyuan Yu, Chao Liang, Quanxia Lv, Defang Li, Xuegong Xu, Baoqin Liu, Aiping Lu, Ge Zhang
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
oligonucleotide aptamers
monoclonal antibodies
diseases therapy
preclinical study
clinical evaluation
Online Access:http://www.mdpi.com/1422-0067/17/3/358

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