Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies. The mechanisms of cisplatin hypersensitivity and resistance in embryonal carcinoma (EC), the st...

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Bibliographic Details
Main Authors: Ratnakar Singh, Zeeshan Fazal, Andrea K. Corbet, Emmanuel Bikorimana, Jennifer C. Rodriguez, Ema M. Khan, Khadeeja Shahid, Sarah J. Freemantle, Michael J. Spinella
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
cisplatin
testicular cancer
polycomb repressive complex
histone methylation
H3K273me
epigenetics
Online Access:https://www.mdpi.com/2072-6694/11/6/796

Internet

https://www.mdpi.com/2072-6694/11/6/796

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