Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis

Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis

BackgroundSevere innate immune suppression, termed immunoparalysis, is associated with increased risks of nosocomial infection and mortality in children with septic shock. Currently, immunoparalysis cannot be clinically diagnosed in children, and mechanisms remain unclear. Transcriptomic studies ide...

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Bibliographic Details
Main Authors: Andrew Snyder, Kathleen Jedreski, James Fitch, Saranga Wijeratne, Amy Wetzel, Josey Hensley, Margaret Flowers, Katherine Bline, Mark W. Hall, Jennifer A. Muszynski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
pediatric
sepsis
innate immunity
adaptive immunity
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.733834/full

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