Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity

Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity

To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug. Medium molecular weight chitosan nanoparticles (MMWCH-NPs) w...

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Bibliographic Details
Main Authors: Aisha Sethi, Mahmood Ahmad, Tayyaba Huma, Waqas Ahmad
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
medium molecular weight chitosan
chemical cross-linking
controlled delivery
5-fluorouracil
tolerability
acute oral toxicity
Online Access:http://dx.doi.org/10.1080/10717544.2021.1944398

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