Nimesulide Induced Histopathological Changes in the Vas Deferens of Mice

• Main Authors: Thotakura Balaji, Manickam Subramanian, Vaithianathan Gnanasundaram, Sharmila Saran Raj Endran, Hannah Sugirthabai Rajila Rajendran
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2013-10-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: nimesulide; vas deferens; cox-2; mice
• Online Access: https://jcdr.net/articles/PDF/3446/3-%206693_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(VH)_PF1(PUH)_PFA(H)_OLF.pdf

Aim: Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty. Aims and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract. Material and Methods: Nimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice. Results: The vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer. Conclusion: Nimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.