Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
Abstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at...
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doaj-e67cbe512f5a40debb243f958e95bf2d2020-11-25T02:02:35ZengBMCInfectious Agents and Cancer1750-93782019-04-011411410.1186/s13027-019-0225-xInfrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective studyBoniface Kofi0Christian Diamant Mossoro-Kpinde1Ralph-Sydney Mboumba Bouassa2Hélène Péré3Leman Robin4Gérard Gresenguet5Laurent Bélec6Laboratoire National de Biologie Clinique et de Santé PubliqueLaboratoire National de Biologie Clinique et de Santé PubliqueEcole Doctorale d’Infectiologie TropicaleAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéFaculté des Sciences de la Santé, Université de BanguiAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéAbstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.http://link.springer.com/article/10.1186/s13027-019-0225-xHPVOropharynxOral cavityCentral AfricaVaccination |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boniface Kofi Christian Diamant Mossoro-Kpinde Ralph-Sydney Mboumba Bouassa Hélène Péré Leman Robin Gérard Gresenguet Laurent Bélec |
spellingShingle |
Boniface Kofi Christian Diamant Mossoro-Kpinde Ralph-Sydney Mboumba Bouassa Hélène Péré Leman Robin Gérard Gresenguet Laurent Bélec Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study Infectious Agents and Cancer HPV Oropharynx Oral cavity Central Africa Vaccination |
author_facet |
Boniface Kofi Christian Diamant Mossoro-Kpinde Ralph-Sydney Mboumba Bouassa Hélène Péré Leman Robin Gérard Gresenguet Laurent Bélec |
author_sort |
Boniface Kofi |
title |
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study |
title_short |
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study |
title_full |
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study |
title_fullStr |
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study |
title_full_unstemmed |
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study |
title_sort |
infrequent detection of human papillomavirus infection in head and neck cancers in the central african republic: a retrospective study |
publisher |
BMC |
series |
Infectious Agents and Cancer |
issn |
1750-9378 |
publishDate |
2019-04-01 |
description |
Abstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic. |
topic |
HPV Oropharynx Oral cavity Central Africa Vaccination |
url |
http://link.springer.com/article/10.1186/s13027-019-0225-x |
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