Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

Abstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at...

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Main Authors: Boniface Kofi, Christian Diamant Mossoro-Kpinde, Ralph-Sydney Mboumba Bouassa, Hélène Péré, Leman Robin, Gérard Gresenguet, Laurent Bélec
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Infectious Agents and Cancer
Subjects:
HPV
Online Access:http://link.springer.com/article/10.1186/s13027-019-0225-x
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spelling doaj-e67cbe512f5a40debb243f958e95bf2d2020-11-25T02:02:35ZengBMCInfectious Agents and Cancer1750-93782019-04-011411410.1186/s13027-019-0225-xInfrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective studyBoniface Kofi0Christian Diamant Mossoro-Kpinde1Ralph-Sydney Mboumba Bouassa2Hélène Péré3Leman Robin4Gérard Gresenguet5Laurent Bélec6Laboratoire National de Biologie Clinique et de Santé PubliqueLaboratoire National de Biologie Clinique et de Santé PubliqueEcole Doctorale d’Infectiologie TropicaleAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéFaculté des Sciences de la Santé, Université de BanguiAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne CitéAbstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.http://link.springer.com/article/10.1186/s13027-019-0225-xHPVOropharynxOral cavityCentral AfricaVaccination
collection DOAJ
language English
format Article
sources DOAJ
author Boniface Kofi
Christian Diamant Mossoro-Kpinde
Ralph-Sydney Mboumba Bouassa
Hélène Péré
Leman Robin
Gérard Gresenguet
Laurent Bélec
spellingShingle Boniface Kofi
Christian Diamant Mossoro-Kpinde
Ralph-Sydney Mboumba Bouassa
Hélène Péré
Leman Robin
Gérard Gresenguet
Laurent Bélec
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
Infectious Agents and Cancer
HPV
Oropharynx
Oral cavity
Central Africa
Vaccination
author_facet Boniface Kofi
Christian Diamant Mossoro-Kpinde
Ralph-Sydney Mboumba Bouassa
Hélène Péré
Leman Robin
Gérard Gresenguet
Laurent Bélec
author_sort Boniface Kofi
title Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_short Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_full Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_fullStr Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_full_unstemmed Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_sort infrequent detection of human papillomavirus infection in head and neck cancers in the central african republic: a retrospective study
publisher BMC
series Infectious Agents and Cancer
issn 1750-9378
publishDate 2019-04-01
description Abstract We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.
topic HPV
Oropharynx
Oral cavity
Central Africa
Vaccination
url http://link.springer.com/article/10.1186/s13027-019-0225-x
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