Impact of nucleos(t)ide analogues on quality of life in patients with chronic hepatitis B

• Main Authors: ZHONG Chunxiu, CAI Shaohang, YIN Junhua
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2016-11-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=7806

ObjectiveTo investigate the impact of treatment with nucleos(t)ide analogues on quality of life (QoL) in patients with chronic hepatitis B (CHB), as well as proper nursing measures. MethodsA total of 102 CHB patients who were treated in Department of Infectious Diseases, Nanfang Hospital, Southern Medical University from March 2010 to July 2014 were enrolled and divided into continuous treatment group (54 patients) and drug withdrawal group (48 patients). The 36-item short-form health survey (SF-36) was used to measure QoL. The patients in the treatment group were evaluated before treatment and at 96 weeks of treatment, and those in the drug withdrawal group were evaluated at the time of drug withdrawal and at 48 weeks after drug withdrawal. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. The logistic regression analysis was performed for univariate and multivariate analyses. ResultsCompared with before treatment, the continuous treatment group had significant increases in the scores on the domains of physiological function, role physical, bodily pain, and general health after 96 weeks of antiviral therapy (physiological function: 94.91±7.11 vs 92.13±10.58, t=-2.924,P＜0.05; role physical: 81.94±24.96 vs 71.76±34.01, t=-2.623,P＜0.05; bodily pain: 87.72±8.64 vs 82.85±12.88, t=-3.576,P＜0.05; general health: 59.63±1459 vs 53.52±16.79, t=-3.786,P＜0.05). As for psychological quality, the continuous treatment group had a significant increase in the subscale of mental health (67.30±18.94 vs 75.56±15.53, t=-3.883,P＜0.001), while there were no significant improvements in other subscales. At 48 weeks after drug withdrawal, the drug withdrawal group had significant increases in role physical (84.20±18.97 vs 72.49±24.38, t=-2.768,P＜0.05), general health (69.28±22.94 vs 56.41±18.27, t=-3.206,P＜0.05), and mental health (75.02±16.03 vs 68.94±14.07, t=-2.078,P＜0.05). The multivariate analysis showed that marital status was associated with theimprovement in QoL after antiviral therapy (odds ratio=11.61, 95%CI:2.28-59.00,P=0.003); the unmarried patients had better improvements in QoL compared with the married ones, especially physiological function (t=-2.176,P=0.034), role physical (t=-2.173,P=0.034), and role emotional (t=-2.811,P=0.007). ConclusionAntiviral therapy can improve the QoL and mental health of CHB patients. Effective psychological intervention is necessary for CHB patients, especially married CHB patients.