Small molecule inhibition of Csk alters affinity recognition by T cells

Small molecule inhibition of Csk alters affinity recognition by T cells

The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling, we utilized a mouse expressing mutated Csk (CskA...

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Bibliographic Details
Main Authors: Boryana N Manz, Ying Xim Tan, Adam H Courtney, Florentine Rutaganira, Ed Palmer, Kevan M Shokat, Arthur Weiss
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
signal transduction
receptor
lymphocyte
Src kinase
tyrosine phosphorylation
Online Access:https://elifesciences.org/articles/08088

Internet

https://elifesciences.org/articles/08088

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