Triacylglycerol synthesis enhances macrophage inflammatory function
As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent...
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| Format: | Article |
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Nature Publishing Group
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17881-3 |
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doaj-e66368483cc344ee9854c2ede5bf41d52021-08-15T11:41:47ZengNature Publishing GroupNature Communications2041-17232020-08-0111111110.1038/s41467-020-17881-3Triacylglycerol synthesis enhances macrophage inflammatory functionAngela Castoldi0Lauar B. Monteiro1Nikki van Teijlingen Bakker2David E. Sanin3Nisha Rana4Mauro Corrado5Alanna M. Cameron6Fabian Hässler7Mai Matsushita8George Caputa9Ramon I. Klein Geltink10Jörg Büscher11Joy Edwards-Hicks12Erika L. Pearce13Edward J. Pearce14Department of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyMetabolomics Facility, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyDepartment of Immunometabolism, Max Planck Institute of Epigenetics and ImmunobiologyAs macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation.https://doi.org/10.1038/s41467-020-17881-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce |
| spellingShingle |
Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce Triacylglycerol synthesis enhances macrophage inflammatory function Nature Communications |
| author_facet |
Angela Castoldi Lauar B. Monteiro Nikki van Teijlingen Bakker David E. Sanin Nisha Rana Mauro Corrado Alanna M. Cameron Fabian Hässler Mai Matsushita George Caputa Ramon I. Klein Geltink Jörg Büscher Joy Edwards-Hicks Erika L. Pearce Edward J. Pearce |
| author_sort |
Angela Castoldi |
| title |
Triacylglycerol synthesis enhances macrophage inflammatory function |
| title_short |
Triacylglycerol synthesis enhances macrophage inflammatory function |
| title_full |
Triacylglycerol synthesis enhances macrophage inflammatory function |
| title_fullStr |
Triacylglycerol synthesis enhances macrophage inflammatory function |
| title_full_unstemmed |
Triacylglycerol synthesis enhances macrophage inflammatory function |
| title_sort |
triacylglycerol synthesis enhances macrophage inflammatory function |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-08-01 |
| description |
As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisite for prostaglandin E2 production and subsequent inflammatory activation. |
| url |
https://doi.org/10.1038/s41467-020-17881-3 |
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